And finally, clonidine enhances neuraxial opioids and, in combination with fentanyl, interacts in an additive fashion, which might reduce the dose of each and every part by 60% for postoperative analgesia. Jun ten, 2024 · If clonidine therapy would be to be replaced by a β-blocker, hold off administration https://www.proleviate.com/post/the-new-pain-killer-conolidine