Evidence-based professional reference pages authored by our clinical team for the use of medical professionals. An acute exacerbation is more commonly known kakım a 'flare-up'. An acute exacerbation of chronic obstructive pulmonary disease (COPD) is a sudden worsening of COPD symptoms compared with the usual severity of symptoms. Your personal https://www.metooo.com/u/672d0b79d5e0d01190f7e891